the synthesis of hydrophobic can be improved, aggregated sequences that contain glycine with the use of DMB Dipeptide Building Blocks.
They work in exactly the same way as pseudoproline dipeptides by exploiting the natural propensity of N-alkyl amino acids to disrupt the formation of the secondary structures during peptide assembly.
Their use can result in better and more predictable acylation and deprotection kinetics, enhanced reaction rates, and improved yields, purities and solubility’s of crude products. They can also increase peptide cyclization efficiency.
DMB dipeptides are fully compatible with standard coupling methods used with reagents such as PyBOP, HBTU, DIC/HOBt or HATU.
Ref: Solid-Phase Peptide Synthesis: An Introduction.Knud J. Jensen