Gastrointestinal Peptides

GI peptides are signal molecules that are released into the blood by the GI cells themselves. They act on a variety of tissues including the brain, digestive accessory organs, and the GI tract. The effects range from excitatory or inhibitory effects on motility and secretion to feelings of satiety or hunger when acting on the brain. These hormones fall into three major categories, the gastrin and secretin families, with the third composed of all the other hormones unlike those in the other two families.

	Secreted By	Target	Effects on Endocrine Secretion	Effects on Exocrine Secretion	Effects on Motility	Stimulus for Release	Other Effects
Gastrin	G Cells in stomach	ECL cells; parietal cells	None	Increases acid secretion, increases mucus growth	None	None	Peptides and amino acids in lumen; gastrin releasing peptide and Ach in nervous reflexes
Cholecystokinin (CCK)	Endocrine cells of the small intestine; neurons of the brain and gut	Gallbladder, pancreas, gastric smooth muscle	None	Stimulates pancreatic enzyme and HCO3- secretion	Stimulates gallbladder contraction; Inhibits stomach emptying	Satiety	Fatty Acids and some Amino acids
Secretin	Endocrine Cells of the Small Intestine	Pancreas, stomach	None	Stimulates pancreatic and hepatic HCO3- secretion; Inhibits acid secretion; Pancreatic growth	Stimulates gallbladder contraction; Inhibits stomach emptying	None	Acid in small intestine
Gastric inhibitory Peptide	Endocrine K Cells of the small intestine	Beta Cells of the pancreas	Stimulates pancreatic insulin release	Inhibits Acid Secretion	None	Satiety and lipid metabolism	Glucose, Fatty Acid, and amino acids in small intestine
Motilin	Endocrine Cells in Small intestine	Smooth muscle of antrum and duodenum	None	None	Stimulates Migrating motor complex	Action in Brain?, Stimulates Migratory Motor Complex	Fasting: Cyclic release every 1.5–2 hours by neural stimulus.
Glucagon Like Peptide 1	Endocrine Cells in Small Intestine	Endocrine Pancreas	Stimulates Insulin release; inhibits glucagon release	Possibly Inhibits Acid Secretion	Slows gastric Emptying	Satiety	Mixed meals of Fats and Carbohydrates.

Displaying 1 to 16 (of 16 products)	Result Pages: 1

	Model	Product Name
	AG-52250	Galanin-human
	AG-52252	Galanin-Porcine
	AG-52251	Galanin-Rat
	AG-52253	Gastrin I-Peptide human
	AG-52164	Gastrin I-Peptide Rat
	AG-52254	Gastrin Releasing Peptide-human
	AG-52255	Gastrin Releasing Peptide-porcine
	AG-55295	Gastrin-Peptide chicken
	AG-55213	Motilin-canine Peptide
	AG-52213	Motilin-porcine Peptide
	AG-52291	PACAP (1-38)- human-ovine-rat
	AG-52292	Pancreastatin Peptide-porcine
	AG-55301	Pancreatic Polypeptide (Pancreatic hormone)-avian
	AG-52293	Pancreatic Polypeptide (Pancreatic hormone)-Human
	AG-55174	Papain Inhibitor peptide
	AG-55310	Pentagastrin Peptide


Displaying 1 to 16 (of 16 products)	Result Pages: 1