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(DPhe7) Bradykinin

Bradykinin raises internal calcium levels in neocortical astrocytes causing them to release glutamate.

Bradykinin is also thought to be the cause of the dry cough in some patients on angiotensin converting enzyme (ACE) inhibitor drugs. This refractory cough is a common cause for stopping ACE inhibitor therapy. In which case Angiotensin II Receptor Antagonists are the next line of treatment.

Sequence: H-Arg-Pro-Pro-Gly-Phe-Ser-D-Phe-Phe-Arg-OH